Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis

Intramembrane-cleaving proteases (I-CLiPs) activate pools of single-pass helical membrane protein signaling precursors that are key in the physiology of prokaryotic and eukaryotic cells. Proteases typically cleave peptide bonds within extended or flexible regions of their substrates, and thus the me...

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Dades bibliogràfiques
Publicat a:Biophys J
Autors principals: Brown, Mia C., Abdine, Alaa, Chavez, Jose, Schaffner, Adam, Torres-Arancivia, Celia, Lada, Brian, JiJi, Renee D., Osman, Roman, Cooley, Jason W., Ubarretxena-Belandia, Iban
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2018
Matèries:
Proteins
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954294/
https://ncbi.nlm.nih.gov/pubmed/29642028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.01.043
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