Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis

Intramembrane-cleaving proteases (I-CLiPs) activate pools of single-pass helical membrane protein signaling precursors that are key in the physiology of prokaryotic and eukaryotic cells. Proteases typically cleave peptide bonds within extended or flexible regions of their substrates, and thus the me...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Brown, Mia C., Abdine, Alaa, Chavez, Jose, Schaffner, Adam, Torres-Arancivia, Celia, Lada, Brian, JiJi, Renee D., Osman, Roman, Cooley, Jason W., Ubarretxena-Belandia, Iban
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2018
Sujets:
Proteins
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954294/
https://ncbi.nlm.nih.gov/pubmed/29642028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.01.043
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