Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis

Intramembrane-cleaving proteases (I-CLiPs) activate pools of single-pass helical membrane protein signaling precursors that are key in the physiology of prokaryotic and eukaryotic cells. Proteases typically cleave peptide bonds within extended or flexible regions of their substrates, and thus the me...

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Detalles Bibliográficos
Publicado en:Biophys J
Autores principales: Brown, Mia C., Abdine, Alaa, Chavez, Jose, Schaffner, Adam, Torres-Arancivia, Celia, Lada, Brian, JiJi, Renee D., Osman, Roman, Cooley, Jason W., Ubarretxena-Belandia, Iban
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2018
Materias:
Proteins
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954294/
https://ncbi.nlm.nih.gov/pubmed/29642028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.01.043
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