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Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis

Intramembrane-cleaving proteases (I-CLiPs) activate pools of single-pass helical membrane protein signaling precursors that are key in the physiology of prokaryotic and eukaryotic cells. Proteases typically cleave peptide bonds within extended or flexible regions of their substrates, and thus the me...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Brown, Mia C., Abdine, Alaa, Chavez, Jose, Schaffner, Adam, Torres-Arancivia, Celia, Lada, Brian, JiJi, Renee D., Osman, Roman, Cooley, Jason W., Ubarretxena-Belandia, Iban
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954294/
https://ncbi.nlm.nih.gov/pubmed/29642028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.01.043
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