Unwinding of the Substrate Transmembrane Helix in Intramembrane Proteolysis

Intramembrane-cleaving proteases (I-CLiPs) activate pools of single-pass helical membrane protein signaling precursors that are key in the physiology of prokaryotic and eukaryotic cells. Proteases typically cleave peptide bonds within extended or flexible regions of their substrates, and thus the me...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Brown, Mia C., Abdine, Alaa, Chavez, Jose, Schaffner, Adam, Torres-Arancivia, Celia, Lada, Brian, JiJi, Renee D., Osman, Roman, Cooley, Jason W., Ubarretxena-Belandia, Iban
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2018
Fag:
Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954294/
https://ncbi.nlm.nih.gov/pubmed/29642028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.01.043
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