Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype

Intramembrane-cleaving proteases (I-CLiPs) catalyze the hydrolysis of peptide bonds within the transmembrane regions of membrane protein substrates, releasing bioactive fragments that play roles in many physiological and pathological processes. Based on their catalytic mechanism and nucleophile, I-C...

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Gepubliceerd in:Front Mol Neurosci
Hoofdauteurs: Liu, Xinyue, Zhao, Jing, Zhang, Yingkai, Ubarretxena-Belandia, Iban, Forth, Scott, Lieberman, Raquel L., Wang, Chunyu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248309/
https://ncbi.nlm.nih.gov/pubmed/32508589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00065
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