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Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
Intramembrane-cleaving proteases (I-CLiPs) catalyze the hydrolysis of peptide bonds within the transmembrane regions of membrane protein substrates, releasing bioactive fragments that play roles in many physiological and pathological processes. Based on their catalytic mechanism and nucleophile, I-C...
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| Pubblicato in: | Front Mol Neurosci |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7248309/ https://ncbi.nlm.nih.gov/pubmed/32508589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00065 |
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