Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype

Intramembrane-cleaving proteases (I-CLiPs) catalyze the hydrolysis of peptide bonds within the transmembrane regions of membrane protein substrates, releasing bioactive fragments that play roles in many physiological and pathological processes. Based on their catalytic mechanism and nucleophile, I-C...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Mol Neurosci
Prif Awduron: Liu, Xinyue, Zhao, Jing, Zhang, Yingkai, Ubarretxena-Belandia, Iban, Forth, Scott, Lieberman, Raquel L., Wang, Chunyu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248309/
https://ncbi.nlm.nih.gov/pubmed/32508589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00065
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