Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype

Intramembrane-cleaving proteases (I-CLiPs) catalyze the hydrolysis of peptide bonds within the transmembrane regions of membrane protein substrates, releasing bioactive fragments that play roles in many physiological and pathological processes. Based on their catalytic mechanism and nucleophile, I-C...

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Detalles Bibliográficos
Publicado en:Front Mol Neurosci
Autores principales: Liu, Xinyue, Zhao, Jing, Zhang, Yingkai, Ubarretxena-Belandia, Iban, Forth, Scott, Lieberman, Raquel L., Wang, Chunyu
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248309/
https://ncbi.nlm.nih.gov/pubmed/32508589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00065
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