Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype

Intramembrane-cleaving proteases (I-CLiPs) catalyze the hydrolysis of peptide bonds within the transmembrane regions of membrane protein substrates, releasing bioactive fragments that play roles in many physiological and pathological processes. Based on their catalytic mechanism and nucleophile, I-C...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Liu, Xinyue, Zhao, Jing, Zhang, Yingkai, Ubarretxena-Belandia, Iban, Forth, Scott, Lieberman, Raquel L., Wang, Chunyu
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248309/
https://ncbi.nlm.nih.gov/pubmed/32508589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00065
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