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Substrate interaction inhibits γ-secretase production of amyloid-β peptides
Combining NMR, mass spectrometry, AlphaLISA and cell assays, we discovered a compound C1 that binds C-terminal juxtamembrane lysines at the transmembrane domain of the amyloid precursor protein (APPTM) and inhibits γ-secretase production of amyloid-β with μM IC(50). Our work suggests that targeting...
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| Izdano u: | Chem Commun (Camb) |
|---|---|
| Glavni autori: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8219260/ https://ncbi.nlm.nih.gov/pubmed/32016207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc09170j |
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