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Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
Intramembrane-cleaving proteases (I-CLiPs) catalyze the hydrolysis of peptide bonds within the transmembrane regions of membrane protein substrates, releasing bioactive fragments that play roles in many physiological and pathological processes. Based on their catalytic mechanism and nucleophile, I-C...
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| Publicado en: | Front Mol Neurosci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7248309/ https://ncbi.nlm.nih.gov/pubmed/32508589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00065 |
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