Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease

The deposition of toxic amyloid-β peptide (Aβ) aggregates in the brain is a hallmark of Alzheimer's disease. The intramembrane proteolysis by γ-secretase of the amyloid precursor protein carboxy-terminal fragment (APP-βCTF) constitutes the final step in the production of Aβs. Mounting evidence...

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Bibliographic Details
Main Authors: Wang, Hao, Barreyro, Laura, Provasi, Davide, Djemil, Imane, Torres-Arancivia, Celia, Filizola, Marta, Ubarretxena-Belandia, Iban
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082318/
https://ncbi.nlm.nih.gov/pubmed/21440556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.028
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