Amyloidogenic Processing but not AICD Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

The β-amyloid peptide (Aβ) is the major constituent of the amyloid core of senile plaques found in the brain of patients with Alzheimer's disease (AD). Aβ is produced by the sequential cleavage of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Cleavage of APP by γ-secretase also ge...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kienlen-Campard, Pascal, Tasiaux, Bernadette, Van Hees, Joanne, Li, Mingli, Huysseune, Sandra, Sato, Takeshi, Fei, Jeffrey Z., Aimoto, Saburo, Courtoy, Pierre J., Smith, Steven O., Constantinescu, Stefan N., Octave, Jean-Noël
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702479/
https://ncbi.nlm.nih.gov/pubmed/18201969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707142200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados