Amyloidogenic Processing but not AICD Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

The β-amyloid peptide (Aβ) is the major constituent of the amyloid core of senile plaques found in the brain of patients with Alzheimer's disease (AD). Aβ is produced by the sequential cleavage of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Cleavage of APP by γ-secretase also ge...

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Détails bibliographiques
Auteurs principaux: Kienlen-Campard, Pascal, Tasiaux, Bernadette, Van Hees, Joanne, Li, Mingli, Huysseune, Sandra, Sato, Takeshi, Fei, Jeffrey Z., Aimoto, Saburo, Courtoy, Pierre J., Smith, Steven O., Constantinescu, Stefan N., Octave, Jean-Noël
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702479/
https://ncbi.nlm.nih.gov/pubmed/18201969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707142200
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