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Copper Abolishes the β-Sheet Secondary Structure of Preformed Amyloid Fibrils of Amyloid-β(42)
The observation of the co-deposition of metals and amyloid-β(42) (Aβ(42)) in brain tissue in Alzheimer’s disease prompted myriad investigations into the role played by metals in the precipitation of this peptide. Copper is bound by monomeric Aβ(42) and upon precipitation of the copper-peptide comple...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857508/ https://ncbi.nlm.nih.gov/pubmed/19749401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-1235 |
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