Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant

Cerebral amyloid angiopathy (CAA) is a vascular disorder that primarily involves deposition of the 40-residue–long β-amyloid peptide (Aβ40) in and along small blood vessels of the brain. CAA is often associated with Alzheimer's disease (AD), which is characterized by amyloid plaques in the brai...

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Udgivet i:J Biol Chem
Main Authors: Crooks, Elliot J., Irizarry, Brandon A., Ziliox, Martine, Kawakami, Toru, Victor, Tiffany, Xu, Feng, Hojo, Hironobu, Chiu, Kelley, Simmerling, Carlos, Van Nostrand, William E., Smith, Steven O., Miller, Lisa M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335782/
https://ncbi.nlm.nih.gov/pubmed/32376688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011955
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