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Evidence for Novel β-Sheet Structures in Iowa Mutant β-Amyloid Fibrils

Asp23-to-Asn mutation within the coding sequence of β-amyloid, called the Iowa mutation, is associated with early onset, familial Alzheimer’s disease and cerebral amyloid angiopathy, in which patients develop neuritic plaques and massive vascular deposition predominantly of the mutant peptide. We ex...

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Sonraí Bibleagrafaíochta
Main Authors: Tycko, Robert, Sciarretta, Kimberly L., Orgel, Joseph P. R. O., Meredith, Stephen C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910621/
https://ncbi.nlm.nih.gov/pubmed/19358576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9002666
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