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Increasing the Amphiphilicity of an Amyloidogenic Peptide Changes the β-Sheet Structure in the Fibrils from Antiparallel to Parallel

Solid-state NMR measurements have been reported for four peptides derived from β-amyloid peptide Aβ(1–42): Aβ(1–40), Aβ(10–35), Aβ(16–22), and Aβ(34–42). Of these, the first two are predicted to be amphiphilic and were reported to form parallel β-sheets, whereas the latter two peptides appear nonamp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gordon, David J., Balbach, John J., Tycko, Robert, Meredith, Stephen C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Biophysical Society 2004
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1303808/
https://ncbi.nlm.nih.gov/pubmed/14695285
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