Učitavanje...
Binding and transport of carboxylated drugs by the multidrug transporter AcrB
AcrAB(Z)-TolC is the main drug efflux transporter complex in Escherichia coli. The extrusion of various toxic compounds depends on several drug binding sites within the trimeric AcrB transporter. Membrane-localized carboxylated substrates, like fusidic acid and hydrophobic β-lactams, access the pump...
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| Izdano u: | J Mol Biol |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7071731/ https://ncbi.nlm.nih.gov/pubmed/31881208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.12.025 |
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