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Binding and transport of carboxylated drugs by the multidrug transporter AcrB
AcrAB(Z)-TolC is the main drug efflux transporter complex in Escherichia coli. The extrusion of various toxic compounds depends on several drug binding sites within the trimeric AcrB transporter. Membrane-localized carboxylated substrates, like fusidic acid and hydrophobic β-lactams, access the pump...
Guardat en:
| Publicat a: | J Mol Biol |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7071731/ https://ncbi.nlm.nih.gov/pubmed/31881208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.12.025 |
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