Binding and transport of carboxylated drugs by the multidrug transporter AcrB

AcrAB(Z)-TolC is the main drug efflux transporter complex in Escherichia coli. The extrusion of various toxic compounds depends on several drug binding sites within the trimeric AcrB transporter. Membrane-localized carboxylated substrates, like fusidic acid and hydrophobic β-lactams, access the pump...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Mol Biol
Main Authors: Tam, Heng-Keat, Malviya, Viveka N., Foong, Wuen-Ee, Herrmann, Andrea, Malloci, Giuliano, Ruggerone, Paolo, Vargiu, Attilio V., Pos, Klaas M.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071731/
https://ncbi.nlm.nih.gov/pubmed/31881208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.12.025
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki