Allosteric drug transport mechanism of multidrug transporter AcrB

Gram-negative bacteria maintain an intrinsic resistance mechanism against entry of noxious compounds by utilizing highly efficient efflux pumps. The E. coli AcrAB-TolC drug efflux pump contains the inner membrane H(+)/drug antiporter AcrB comprising three functionally interdependent protomers, cycli...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Tam, Heng-Keat, Foong, Wuen Ee, Oswald, Christine, Herrmann, Andrea, Zeng, Hui, Pos, Klaas M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8242077/
https://ncbi.nlm.nih.gov/pubmed/34188038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24151-3
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