Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance. Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics. Chlorpromazine and amitriptyline have been shown to behave as efflux inhibitors. However, their mode of ac...

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Veröffentlicht in:mBio
Hauptverfasser: Grimsey, Elizabeth M., Fais, Chiara, Marshall, Robert L., Ricci, Vito, Ciusa, Maria Laura, Stone, Jack W., Ivens, Alasdair, Malloci, Giuliano, Ruggerone, Paolo, Vargiu, Attilio V., Piddock, Laura J. V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7267879/
https://ncbi.nlm.nih.gov/pubmed/32487753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00465-20
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