Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

AcrAB-TolC is the paradigm resistance-nodulation-division (RND) multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex. We constructed a nonfunctional AcrB mutant by replacing D408, a highly conserved residue essential for proton translocation....

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Détails bibliographiques
Publié dans:mBio
Auteurs principaux: Wang-Kan, Xuan, Blair, Jessica M. A., Chirullo, Barbara, Betts, Jonathan, La Ragione, Roberto M., Ivens, Alasdair, Ricci, Vito, Opperman, Timothy J., Piddock, Laura J. V.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516257/
https://ncbi.nlm.nih.gov/pubmed/28720734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00968-17
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