Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design

OBJECTIVES: Enterobacteriaceae have multiple efflux pumps that confer intrinsic resistance to antibiotics. AcrB mediates clinically relevant multidrug resistance and is required for virulence and biofilm formation, making it an attractive target for the design of inhibitors. The aim of this study wa...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Antimicrob Chemother
Auteurs principaux: Blair, Jessica M. A., Smith, Helen E., Ricci, Vito, Lawler, Amelia J., Thompson, Louisa J., Piddock, Laura J. V.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291234/
https://ncbi.nlm.nih.gov/pubmed/25288678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku380
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