Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance. Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics. Chlorpromazine and amitriptyline have been shown to behave as efflux inhibitors. However, their mode of ac...

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Bibliografische gegevens
Gepubliceerd in:mBio
Hoofdauteurs: Grimsey, Elizabeth M., Fais, Chiara, Marshall, Robert L., Ricci, Vito, Ciusa, Maria Laura, Stone, Jack W., Ivens, Alasdair, Malloci, Giuliano, Ruggerone, Paolo, Vargiu, Attilio V., Piddock, Laura J. V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7267879/
https://ncbi.nlm.nih.gov/pubmed/32487753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00465-20
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