Estrogen Stimulation of Pleiotrophin Enhances Osteoblast Differentiation and Maintains Bone Mass in IGFBP-2 Null Mice

Insulin-like growth factor binding protein-2 (IGFBP-2) stimulates osteoblast differentiation but only male Igfbp2 null mice have a skeletal phenotype. The trophic actions of IGFBP-2 in bone are mediated through its binding to receptor tyrosine phosphatase beta (RPTPβ). Another important ligand for R...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Xi, Gang, Demambro, Victoria E, D’Costa, Susan, Xia, Shalier K, Cox, Zach C, Rosen, Clifford J, Clemmons, David R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069688/
https://ncbi.nlm.nih.gov/pubmed/32168373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqz007
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