IGF-I and IGFBP-2 Stimulate AMPK Activation and Autophagy, Which Are Required for Osteoblast Differentiation

IGF-I/insulin-like growth factor binding protein 2 (IGFBP-2) coordinately stimulate osteoblast differentiation but the mechanisms by which they function have not been determined. AMP-activated protein kinase (AMPK) is induced during differentiation and AMPK knockout mice have reduced bone mass. IGF-...

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Bibliografiska uppgifter
I publikationen:Endocrinology
Huvudupphovsmän: Xi, Gang, Rosen, Clifford J., Clemmons, David R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Endocrine Society 2016
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701891/
https://ncbi.nlm.nih.gov/pubmed/26556533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1690
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