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IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation

Insulin like growth factor I (IGF-I) and insulin like growth factor binding protein-2 (IGFBP-2) function coordinately to stimulate AKT and osteoblast differentiation. IGFBP-2 binding to receptor protein tyrosine phosphatase β (RPTPβ) stimulates polymerization and inactivation of phosphatase activity...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Xi, Gang, Shen, Xinchun, Rosen, Clifford J, Clemmons, David R
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5228590/
https://ncbi.nlm.nih.gov/pubmed/26773517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2791
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