Gender-Specific Changes in Bone Turnover and Skeletal Architecture in Igfbp-2-Null Mice

IGF-binding protein-2 (IGFBP-2) is a 36-kDa protein that binds to the IGFs with high affinity. To determine its role in bone turnover, we compared Igfbp2(−/−) mice with Igfbp2(+/+) colony controls. Igfbp2(−/−) males had shorter femurs and were heavier than controls but were not insulin resistant. Se...

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Detalhes bibliográficos
Main Authors: DeMambro, V. E., Clemmons, D. R., Horton, L. G., Bouxsein, M. L., Wood, T. L., Beamer, W. G., Canalis, E., Rosen, C. J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329262/
https://ncbi.nlm.nih.gov/pubmed/18276763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1068
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