The Heparin-binding Domain of IGFBP-2 Has Insulin-like Growth Factor Binding-independent Biologic Activity in the Growing Skeleton

Insulin-like growth factor-binding protein 2 (IGFBP-2) is a member of a family of six highly conserved IGFBPs that are carriers for the insulin-like growth factors (IGFs). IGFBP-2 levels rise during rapid neonatal growth and at the time of peak bone acquisition. In contrast, Igfbp2(−/−) mice have lo...

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Detalhes bibliográficos
Main Authors: Kawai, Masanobu, Breggia, Anne C., DeMambro, Victoria E., Shen, Xinchun, Canalis, Ernesto, Bouxsein, Mary L., Beamer, Wesley G., Clemmons, David R., Rosen, Clifford J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077664/
https://ncbi.nlm.nih.gov/pubmed/21372140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193334
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