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Insulin-like growth factor binding protein-2 is required for osteoclast differentiation

Global deletion of the Igfbp2 gene results in the suppression of bone turnover. To investigate the role of IGFBP-2 in regulating osteoclast differentiation we cultured Igfbp2(−/−) bone marrow cells and found a reduction in the number of osteoclasts and impaired resorption. Addition of full length IG...

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Autors principals: DeMambro, Victoria E, Maile, Laura, Wai, Christine, Kawai, Masanobu, Cascella, Teresa, Rosen, Clifford J, Clemmons, David
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3385417/
https://ncbi.nlm.nih.gov/pubmed/22006816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.545
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