Druggability profile of stilbene-derived PPAR agonists: determination of physicochemical properties and PAMPA study

PPAR agonists represent a new therapeutic opportunity for the prevention and treatment of neurodegenerative disorders, but their pharmacological success depends on favourable pharmacokinetic properties and capability to cross the BBB. In this study, we assayed some PPAR agonists previously synthesiz...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Linciano, Pasquale, De Filippis, Barbara, Ammazzalorso, Alessandra, Amoia, Pasquale, Cilurzo, Felisa, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Petit, Charlotte, Amoroso, Rosa
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069374/
https://ncbi.nlm.nih.gov/pubmed/32206235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00286c
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