Druggability profile of stilbene-derived PPAR agonists: determination of physicochemical properties and PAMPA study

PPAR agonists represent a new therapeutic opportunity for the prevention and treatment of neurodegenerative disorders, but their pharmacological success depends on favourable pharmacokinetic properties and capability to cross the BBB. In this study, we assayed some PPAR agonists previously synthesiz...

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Bibliografski detalji
Izdano u:Medchemcomm
Glavni autori: Linciano, Pasquale, De Filippis, Barbara, Ammazzalorso, Alessandra, Amoia, Pasquale, Cilurzo, Felisa, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Petit, Charlotte, Amoroso, Rosa
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2019
Teme:
Chemistry
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069374/
https://ncbi.nlm.nih.gov/pubmed/32206235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00286c
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