Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies

A large library of fibrate-based N-acylsulphonamides was designed, synthesised, and fully characterised in order to propose them as zinc binders for the inhibition of human carbonic anhydrase (hCA) enzymatic activity. Synthesised compounds were tested against four hCAs (I, II, IX, and XII) revealing...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Ammazzalorso, Alessandra, Carradori, Simone, Angeli, Andrea, Akdemir, Atilla, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Amoroso, Rosa, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522927/
https://ncbi.nlm.nih.gov/pubmed/31074307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1611801
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