Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking

FXR is a member of the nuclear receptor superfamily, which regulates the expression of various genes involved in bile acid, lipid and glucose metabolism. Targeting FXR with small molecules has been exploited to treat lipid-related disorders and diseases such as cholestasis, gallstones and hepatic di...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Medchemcomm
Prif Awduron: Giancristofaro, Antonella, Barbosa, Arménio J. M., Ammazzalorso, Alessandra, Amoia, Pasquale, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Amoroso, Rosa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2018
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194413/
https://ncbi.nlm.nih.gov/pubmed/30393515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00272j
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