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Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking
FXR is a member of the nuclear receptor superfamily, which regulates the expression of various genes involved in bile acid, lipid and glucose metabolism. Targeting FXR with small molecules has been exploited to treat lipid-related disorders and diseases such as cholestasis, gallstones and hepatic di...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6194413/ https://ncbi.nlm.nih.gov/pubmed/30393515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00272j |
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