Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking

FXR is a member of the nuclear receptor superfamily, which regulates the expression of various genes involved in bile acid, lipid and glucose metabolism. Targeting FXR with small molecules has been exploited to treat lipid-related disorders and diseases such as cholestasis, gallstones and hepatic di...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Medchemcomm
Asıl Yazarlar: Giancristofaro, Antonella, Barbosa, Arménio J. M., Ammazzalorso, Alessandra, Amoia, Pasquale, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Amoroso, Rosa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2018
Konular:
Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194413/
https://ncbi.nlm.nih.gov/pubmed/30393515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00272j
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