Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies

A large library of fibrate-based N-acylsulphonamides was designed, synthesised, and fully characterised in order to propose them as zinc binders for the inhibition of human carbonic anhydrase (hCA) enzymatic activity. Synthesised compounds were tested against four hCAs (I, II, IX, and XII) revealing...

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Publicat a:J Enzyme Inhib Med Chem
Autors principals: Ammazzalorso, Alessandra, Carradori, Simone, Angeli, Andrea, Akdemir, Atilla, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Amoroso, Rosa, Supuran, Claudiu T.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522927/
https://ncbi.nlm.nih.gov/pubmed/31074307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1611801
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