Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome

[Image: see text] The development of PPARα/γ dual or PPARα/γ/δ pan-agonists could represent an efficacious approach for a simultaneous pharmacological intervention on carbohydrate and lipid metabolism. Two series of new phenyldiazenyl fibrate derivatives of GL479, a previously reported PPARα/γ dual...

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Udgivet i:ACS Med Chem Lett
Main Authors: Giampietro, Letizia, Laghezza, Antonio, Cerchia, Carmen, Florio, Rosalba, Recinella, Lucia, Capone, Fabio, Ammazzalorso, Alessandra, Bruno, Isabella, De Filippis, Barbara, Fantacuzzi, Marialuigia, Ferrante, Claudio, Maccallini, Cristina, Tortorella, Paolo, Verginelli, Fabio, Brunetti, Luigi, Cama, Alessandro, Amoroso, Rosa, Loiodice, Fulvio, Lavecchia, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466826/
https://ncbi.nlm.nih.gov/pubmed/30996794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00574
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