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MutaBind2: Predicting the Impacts of Single and Multiple Mutations on Protein-Protein Interactions
Missense mutations may affect proteostasis by destabilizing or over-stabilizing protein complexes and changing the pathway flux. Predicting the effects of stabilizing mutations on protein-protein interactions is notoriously difficult because existing experimental sets are skewed toward mutations red...
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| Pubblicato in: | iScience |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7068639/ https://ncbi.nlm.nih.gov/pubmed/32169820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100939 |
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