MutaBind2: Predicting the Impacts of Single and Multiple Mutations on Protein-Protein Interactions

Missense mutations may affect proteostasis by destabilizing or over-stabilizing protein complexes and changing the pathway flux. Predicting the effects of stabilizing mutations on protein-protein interactions is notoriously difficult because existing experimental sets are skewed toward mutations red...

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Veröffentlicht in:iScience
Hauptverfasser: Zhang, Ning, Chen, Yuting, Lu, Haoyu, Zhao, Feiyang, Alvarez, Roberto Vera, Goncearenco, Alexander, Panchenko, Anna R., Li, Minghui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068639/
https://ncbi.nlm.nih.gov/pubmed/32169820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100939
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