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Predicting the Impact of Missense Mutations on Protein–Protein Binding Affinity
[Image: see text] The crucial prerequisite for proper biological function is the protein’s ability to establish highly selective interactions with macromolecular partners. A missense mutation that alters the protein binding affinity may cause significant perturbations or complete abolishment of the...
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| Main Authors: | , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2014
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985714/ https://ncbi.nlm.nih.gov/pubmed/24803870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct401022c |
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