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Predicting the Impact of Missense Mutations on Protein–Protein Binding Affinity

[Image: see text] The crucial prerequisite for proper biological function is the protein’s ability to establish highly selective interactions with macromolecular partners. A missense mutation that alters the protein binding affinity may cause significant perturbations or complete abolishment of the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Li, Minghui, Petukh, Marharyta, Alexov, Emil, Panchenko, Anna R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985714/
https://ncbi.nlm.nih.gov/pubmed/24803870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct401022c
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