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Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

Many studies have shown that missense mutations might play an important role in carcinogenesis. However, the extent to which cancer mutations might affect biomolecular interactions remains unclear. Here, we map glioblastoma missense mutations on the human protein interactome, model the structures of...

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Detalhes bibliográficos
Main Authors: Nishi, Hafumi, Tyagi, Manoj, Teng, Shaolei, Shoemaker, Benjamin A., Hashimoto, Kosuke, Alexov, Emil, Wuchty, Stefan, Panchenko, Anna R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682950/
https://ncbi.nlm.nih.gov/pubmed/23799087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066273
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