Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

Many studies have shown that missense mutations might play an important role in carcinogenesis. However, the extent to which cancer mutations might affect biomolecular interactions remains unclear. Here, we map glioblastoma missense mutations on the human protein interactome, model the structures of...

Full description

Saved in:
Bibliographic Details
Main Authors: Nishi, Hafumi, Tyagi, Manoj, Teng, Shaolei, Shoemaker, Benjamin A., Hashimoto, Kosuke, Alexov, Emil, Wuchty, Stefan, Panchenko, Anna R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682950/
https://ncbi.nlm.nih.gov/pubmed/23799087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066273
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items