Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

Many studies have shown that missense mutations might play an important role in carcinogenesis. However, the extent to which cancer mutations might affect biomolecular interactions remains unclear. Here, we map glioblastoma missense mutations on the human protein interactome, model the structures of...

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Main Authors: Nishi, Hafumi, Tyagi, Manoj, Teng, Shaolei, Shoemaker, Benjamin A., Hashimoto, Kosuke, Alexov, Emil, Wuchty, Stefan, Panchenko, Anna R.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682950/
https://ncbi.nlm.nih.gov/pubmed/23799087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066273
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