Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

Many studies have shown that missense mutations might play an important role in carcinogenesis. However, the extent to which cancer mutations might affect biomolecular interactions remains unclear. Here, we map glioblastoma missense mutations on the human protein interactome, model the structures of...

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Detaylı Bibliyografya
Asıl Yazarlar: Nishi, Hafumi, Tyagi, Manoj, Teng, Shaolei, Shoemaker, Benjamin A., Hashimoto, Kosuke, Alexov, Emil, Wuchty, Stefan, Panchenko, Anna R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682950/
https://ncbi.nlm.nih.gov/pubmed/23799087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066273
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