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Intranasal administration of dantrolene increased brain concentration and duration

Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene’s limited penetration into the CNS hampers its effectiveness as a neuroprotective agent. Here, we studied whether the intranasal administration of dantrolene provided better penetratio...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Wang, Jintao, Shi, Yun, Yu, Shuchun, Wang, Yan, Meng, Qingcheng, Liang, Ge, Eckenhoff, Maryellen F., Wei, Huafeng
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065741/
https://ncbi.nlm.nih.gov/pubmed/32160210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229156
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