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Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice
Disruption of intracellular calcium homeostasis via abnormal and excessive activation of ryanodine receptors plays an important role in the neuropathology of Alzheimer’s disease. We investigated the therapeutic effect of dantrolene, a ryanodine receptor antagonist, on cognitive dysfunction and neuro...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351794/ https://ncbi.nlm.nih.gov/pubmed/22516463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2012.04.008 |
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