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Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

Disruption of intracellular calcium homeostasis via abnormal and excessive activation of ryanodine receptors plays an important role in the neuropathology of Alzheimer’s disease. We investigated the therapeutic effect of dantrolene, a ryanodine receptor antagonist, on cognitive dysfunction and neuro...

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Main Authors: Peng, Jun, Liang, Ge, Inan, Saddet, Wu, Zhen, Joseph, Donald J., Meng, Qingcheng, Peng, Yi, Eckenhoff, Maryellen F., Wei, Huafeng
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351794/
https://ncbi.nlm.nih.gov/pubmed/22516463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2012.04.008
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