Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice

BACKGROUND/OBJECTIVE: This study compares the effectiveness and safety of intranasal versus subcutaneous administration of dantrolene in 5XFAD Alzheimer’s disease (AD) mice. METHODS: 5XFAD and wild type (WT) B6SJLF1/J mice were treated with intranasal or subcutaneous dantrolene (5 mg/kg, 3×/wk), or...

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Detaylı Bibliyografya
Yayımlandı:J Alzheimers Dis
Asıl Yazarlar: Shi, Yun, Zhang, Lei, Gao, Xue, Zhang, Jing, Ben Abou, Matan, Liang, Ge, Meng, Qingcheng, Hepner, Adrian, Eckenhoff, Maryellen F., Wei, Huafeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: IOS Press 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505009/
https://ncbi.nlm.nih.gov/pubmed/32623395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-200227
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