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Intranasal administration of dantrolene increased brain concentration and duration

Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene’s limited penetration into the CNS hampers its effectiveness as a neuroprotective agent. Here, we studied whether the intranasal administration of dantrolene provided better penetratio...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Wang, Jintao, Shi, Yun, Yu, Shuchun, Wang, Yan, Meng, Qingcheng, Liang, Ge, Eckenhoff, Maryellen F., Wei, Huafeng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065741/
https://ncbi.nlm.nih.gov/pubmed/32160210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229156
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