PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats

Reactive oxygen species (ROS), mitochondrial dysfunction, and excessive vasoconstriction are important contributors to chronic hypoxia (CH)-induced neonatal pulmonary hypertension. On the basis of evidence that PKCβ and mitochondrial oxidative stress are involved in several cardiovascular and metabo...

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Publicat a:Am J Physiol Heart Circ Physiol
Autors principals: Sheak, Joshua R., Yan, Simin, Weise-Cross, Laura, Ahmadian, Rosstin, Walker, Benjimen R., Jernigan, Nikki L., Resta, Thomas C.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052628/
https://ncbi.nlm.nih.gov/pubmed/31922892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00629.2019
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