Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity after chronic hypoxia

Chronic hypoxia (CH) augments basal and endothelin-1 (ET-1)-induced pulmonary vasoconstrictor reactivity through reactive oxygen species (ROS) generation and RhoA/Rho kinase (ROCK)-dependent myofilament Ca(2+) sensitization. Because ROCK promotes actin polymerization and the actin cytoskeleton regul...

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Bibliographic Details
Published in:Am J Physiol Heart Circ Physiol
Main Authors: Weise-Cross, Laura, Sands, Michelle A., Sheak, Joshua R., Broughton, Brad R. S., Snow, Jessica B., Gonzalez Bosc, Laura V., Jernigan, Nikki L., Walker, Benjimen R., Resta, Thomas C.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008138/
https://ncbi.nlm.nih.gov/pubmed/29373038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00664.2017
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