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Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity after chronic hypoxia
Chronic hypoxia (CH) augments basal and endothelin-1 (ET-1)-induced pulmonary vasoconstrictor reactivity through reactive oxygen species (ROS) generation and RhoA/Rho kinase (ROCK)-dependent myofilament Ca(2+) sensitization. Because ROCK promotes actin polymerization and the actin cytoskeleton regul...
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| 出版年: | Am J Physiol Heart Circ Physiol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008138/ https://ncbi.nlm.nih.gov/pubmed/29373038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00664.2017 |
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