Augmented Pulmonary Vasoconstrictor Reactivity after Chronic Hypoxia Requires Src Kinase and Epidermal Growth Factor Receptor Signaling

Chronic hypoxia augments pressure- and agonist-induced pulmonary vasoconstriction through myofilament calcium sensitization. NADPH oxidases contribute to the development of pulmonary hypertension, and both epidermal growth factor receptor and Src kinases can regulate NADPH oxidase. We tested the hyp...

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Dades bibliogràfiques
Publicat a:Am J Respir Cell Mol Biol
Autors principals: Norton, Charles E., Sheak, Joshua R., Yan, Simin, Weise-Cross, Laura, Jernigan, Nikki L., Walker, Benjimen R., Resta, Thomas C.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2020
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938133/
https://ncbi.nlm.nih.gov/pubmed/31264901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2018-0106OC
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