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Augmented Pulmonary Vasoconstrictor Reactivity after Chronic Hypoxia Requires Src Kinase and Epidermal Growth Factor Receptor Signaling

Chronic hypoxia augments pressure- and agonist-induced pulmonary vasoconstriction through myofilament calcium sensitization. NADPH oxidases contribute to the development of pulmonary hypertension, and both epidermal growth factor receptor and Src kinases can regulate NADPH oxidase. We tested the hyp...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Norton, Charles E., Sheak, Joshua R., Yan, Simin, Weise-Cross, Laura, Jernigan, Nikki L., Walker, Benjimen R., Resta, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938133/
https://ncbi.nlm.nih.gov/pubmed/31264901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2018-0106OC
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