Intermittent hypoxia augments pulmonary vascular smooth muscle reactivity to NO: regulation by reactive oxygen species

Intermittent hypoxia (IH) resulting from sleep apnea can lead to pulmonary hypertension. IH causes oxidative stress that may limit bioavailability of the endothelium-derived vasodilator nitric oxide (NO) and thus contribute to this hypertensive response. We therefore hypothesized that increased vasc...

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Bibliographic Details
Main Authors: Norton, Charles E., Jernigan, Nikki L., Kanagy, Nancy L., Walker, Benjimen R., Resta, Thomas C.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191795/
https://ncbi.nlm.nih.gov/pubmed/21757577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01286.2010
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