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Chronic hypoxia augments depolarization-induced Ca(2+) sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA

Rho kinase (ROCK)-dependent vasoconstriction has been implicated as a major factor in chronic hypoxia (CH)-induced pulmonary hypertension. This component of pulmonary hypertension is associated with arterial myogenicity and increased vasoreactivity to receptor-mediated agonists and depolarizing stim...

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Detalhes bibliográficos
Main Authors: Broughton, Brad R. S., Jernigan, Nikki L., Norton, Charles E., Walker, Benjimen R., Resta, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822557/
https://ncbi.nlm.nih.gov/pubmed/19897743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00276.2009
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