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Chronic hypoxia augments depolarization-induced Ca(2+) sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA
Rho kinase (ROCK)-dependent vasoconstriction has been implicated as a major factor in chronic hypoxia (CH)-induced pulmonary hypertension. This component of pulmonary hypertension is associated with arterial myogenicity and increased vasoreactivity to receptor-mediated agonists and depolarizing stim...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Physiological Society
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822557/ https://ncbi.nlm.nih.gov/pubmed/19897743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00276.2009 |
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