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Reactive oxygen species mediate RhoA/Rho kinase-induced Ca(2+) sensitization in pulmonary vascular smooth muscle following chronic hypoxia
Recent evidence supports a prominent role for Rho kinase (ROK)-mediated pulmonary vasoconstriction in the development and maintenance of chronic hypoxia (CH)-induced pulmonary hypertension. Endothelin (ET)-1 contributes to the pulmonary hypertensive response to CH, and recent studies by our laborato...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2536792/ https://ncbi.nlm.nih.gov/pubmed/18621909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00355.2007 |
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