Accumulation of succinate controls activation of adipose tissue thermogenesis

Brown and beige adipose tissue thermogenesis can combat metabolic disease, which requires activation by extrinsic stimuli(1). Adipocyte lipolysis through cAMP/PKA signaling initiates thermogenic respiration, and this pathway has been subject to longstanding clinical investigation(2–4). Here we apply...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Mills, Evanna L., Pierce, Kerry A., Jedrychowski, Mark P., Garrity, Ryan, Winther, Sally, Vidoni, Sara, Yoneshiro, Takeshi, Spinelli, Jessica B., Lu, Gina Z., Kazak, Lawrence, Banks, Alexander S., Haigis, Marcia C., Kajimura, Shingo, Murphy, Michael P., Gygi, Steven P., Clish, Clary B., Chouchani, Edward T.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045287/
https://ncbi.nlm.nih.gov/pubmed/30022159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0353-2
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