Accumulation of succinate controls activation of adipose tissue thermogenesis

Brown and beige adipose tissue thermogenesis can combat metabolic disease, which requires activation by extrinsic stimuli(1). Adipocyte lipolysis through cAMP/PKA signaling initiates thermogenic respiration, and this pathway has been subject to longstanding clinical investigation(2–4). Here we apply...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Mills, Evanna L., Pierce, Kerry A., Jedrychowski, Mark P., Garrity, Ryan, Winther, Sally, Vidoni, Sara, Yoneshiro, Takeshi, Spinelli, Jessica B., Lu, Gina Z., Kazak, Lawrence, Banks, Alexander S., Haigis, Marcia C., Kajimura, Shingo, Murphy, Michael P., Gygi, Steven P., Clish, Clary B., Chouchani, Edward T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045287/
https://ncbi.nlm.nih.gov/pubmed/30022159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0353-2
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