Accumulation of succinate controls activation of adipose tissue thermogenesis

Brown and beige adipose tissue thermogenesis can combat metabolic disease, which requires activation by extrinsic stimuli(1). Adipocyte lipolysis through cAMP/PKA signaling initiates thermogenic respiration, and this pathway has been subject to longstanding clinical investigation(2–4). Here we apply...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nature
Päätekijät: Mills, Evanna L., Pierce, Kerry A., Jedrychowski, Mark P., Garrity, Ryan, Winther, Sally, Vidoni, Sara, Yoneshiro, Takeshi, Spinelli, Jessica B., Lu, Gina Z., Kazak, Lawrence, Banks, Alexander S., Haigis, Marcia C., Kajimura, Shingo, Murphy, Michael P., Gygi, Steven P., Clish, Clary B., Chouchani, Edward T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045287/
https://ncbi.nlm.nih.gov/pubmed/30022159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0353-2
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